Biological signaling pathways and potential mathematical network representations: biological discovery through optimization

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Biological network design strategies: discovery through dynamic optimization.

An important challenge in systems biology is the inherent complexity of biological network models, which complicates the task of relating network structure to function and of understanding the conceptual design principles by which a given network operates. Here we investigate an approach to analyze the relationship between a network structure and its function using the framework of optimization...

متن کامل

A tutorial on mathematical modeling of biological signaling pathways.

Mathematical models have been widely used in the studies of biological signaling pathways. Among these studies, two systems biology approaches have been applied: top-down and bottom-up systems biology. The former approach focuses on X-omics researches involving the measurement of experimental data in a large scale, for example proteomics, metabolomics, or fluxomics and transcriptomics. In contr...

متن کامل

Biological Network Alignment Through Multiobjective Metaheuristic Optimization

As biological inquiry produces ever more network data, such as protein-protein interaction networks, gene regulatory networks, and metabolic networks, many algorithms have been proposed for the purpose of pairwise network alignment– finding a mapping from the nodes of one network to the nodes of another in such a way that the mapped nodes can be considered to correspond with respect to both the...

متن کامل

Biological Network Representations and Databases

Transcriptional Regulatory Networks. In transcription regulatory networks the nodes represent transcription factors and genes while the links describe regulation-based interactions. Each link is directed, pointing from the transcription factor to the gene that it regulates. To compare the topological properties of transcription-regulatory networks to those of metabolic and protein-protein inter...

متن کامل

Mathematical Modeling of Biological Signaling Networks

Intracellular signaling networks, which are composed of interconnected biochemical pathways, regulate and actuate responses such as cell-cycle progression and cell migration, survival, and differentiation. Although our knowledge of the intricate biochemical mechanisms at the level of individual proteins and molecular interactions is ever expanding, those details leave us with an even murkier vi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Cancer Medicine

سال: 2018

ISSN: 2045-7634

DOI: 10.1002/cam4.1301